Antonio Conte suffers his first defeat with Tottenham as the Lillywhites are stained with a 2:1 defeat to lowly NS Mura in Europe conference league on Thursday night
Horvat took a shocking lead in the 11 minute to put a team formed in year 2012 a goal up before Sessegnon was red carded 20 minutes later.
A disappointing halftime finish for the visitors. Harry Kane got an equalizer for Tottenham with 20 minutes left to play while Marosa sealed a sensational win for the host late in the 90 minutes.
Tottenham will now have to fight on the last day for a qualification into next round as they are leveled on points with third place Vitesse Arhem who are on seven points.
Meanwhile, Jose Mourinho’s Roma secured a place in the next round in group C with an emphatic 4:0 Victory over FK Zorya Luhansk.
Tammy Abraham got a brace while Perez and Zaniolo were also on point for the host.
In the Eurpopa league, Yarmolenko and Noble both scored to ensure West Ham continue their unbeaten run in the competition.
West Ham tops group H with 13 points and are already through to the next round with a game to spare.
For other results Leicester City rekindled their hope of next round with a 3:1 win over Legia Warsaw of Poland to record 8 points top in group C
Super Eagles midfielder Wilfred Ndidi got the third goal for the Foxes after Patson Daka and Maddison have scored 11 and 21 minute respectively.
Mladenovic ensured it was not a barren night for the visitors bringing the scoreline to 3:1.
This result means that any of the four teams in group C (Napoli, Legia Warsaw, Leicester City and Spartak Moscow) still have a chance of entering into the next round heading into the last game of group stage.
Monaco’s 2:1 win over Spain’s Real Sociedad bagged next round spot for the French side.
Volland goal was cancelled by Isak of Real Sociedad before Fofana who was later sent off by the referee late in the 89 minute sealed the victory for 11 points.